OMEICOS Therapeutics Closes €17m Series C Financing

OMEICOS Therapeutics, a Berlin-based biopharmaceutical company developing first-in-class small molecule therapeutics for the prevention and treatment of cardiovascular and ophthalmic diseases, today announced the closing of a EUR 17 million (approx. USD 19.5 million) Series C financing led by new investor Forbion. Existing investors Vesalius Biocapital II S.A. SICAR, Remiges BioPharma Fund, SMS group GmbH, KFW Group, VC Fonds Technologie Berlin, High-Tech Gründerfonds II GmbH & Co. KG and The Falck Revocable Trust participated as well. The proceeds from this round will finance PROMISE-AF, a placebo controlled, double-blinded, randomized, dose finding Phase II study on OMT-28 in maintenance of sinus rhythm after electrical cardioversion in patients with persistent atrial fibrillation. Additionally, OMEICOS will continue to drive the expansion of its pipeline into novel indications including ophthalmology, led by its US-based subsidiary OMEICOS Ophthalmics.

“This financing arrives in a particularly exciting time for the OMEICOS team as we accelerate plans to initiate our Phase II study of OMT-28, OMEICOS’ novel safe rhythm stabilizer developed for patients with atrial fibrillation. The investment of Forbion confirms the excellent work of the entire team and supports our ambitious plans in atrial fibrillation and other indications,” commented Robert Fischer, MD, CEO/CSO of OMEICOS Therapeutics.

Holger Reithinger, Ph.D. General Partner at Forbion added: “We’ve been following the OMEICOS story for some time and are very positive about the progress. The unique concept of a novel treatment for atrial fibrillation together with the excellent safety data of OMT-28 convinced us to invest and support the future growth of the company.”

Christian Schneider, Ph.D. Managing Partner at Vesalius Biocapital commented: “The addition of Forbion is another consequent step in the successful development of OMEICOS. The shareholders highly welcome Forbion’s commitment to join forces in order to accelerate the company’s development pipeline in indications with high unmet medical need.”

Martin Pfister, Ph.D. Sen. Investment Manager at High-Tech Gruenderfonds commented: “HTGF, the first investor in OMEICOS` seed round in 2013 is very happy to see the company taking a big next step towards a new-in class drug product. With Forbion, we get one of the most renowned European LifeScience investors on board.”

OMEICOS is developing first-in-class small molecule therapeutics for the prevention and treatment of cardiovascular and ophthalmic diseases. The compounds are synthetic analogs of naturally occurring, but metabolically unstable, metabolites of omega-3 fatty acids that can activate anti-arrhythmic, cardio protective and anti-inflammatory pathways. OMEICOS’ first-in-class small molecules can be administered orally and have shown improved biological activity and pharmacokinetic properties compared to their natural counterparts. Atrial fibrillation is the most common type of heart arrhythmia affecting an estimated 33.5 million people worldwide. Incidence is expected to increase over the next decade as life expectancy increases. The disease is associated with significant health risks and current therapies have limited efficacy and safety.

OMEICOS Ophthalmics was established in Boston, MA, USA in August 2017 to focus on a clinical development program for OMEICOS’ ophthalmological drug indications. OMEICOS’ compounds are currently in preclinical development for macular edema disease, including wet age-related macular degeneration (AMD) and diabetic retinopathy. New treatments for wet AMD are needed to reduce the burden of repeated, frequent injections of therapeutics into the eye, and to offer more convenient routes of administration.

About OMEICOS
OMEICOS Therapeutics is a spin-off company from the Max Delbrueck Center for Molecular Medicine (MDC) in Berlin. The company has discovered a series of metabolically robust synthetic analogues of omega-3 fatty acid-derived epoxyeicosanoids that have the potential to treat inflammatory, cardiovascular and other diseases. Epoxyeicosanoids, as a newly described class of bioactive lipid mediators, activate cell type-specific endogenous pathways that promote organ and tissue protection. OMEICOS’ small molecules are orally available and show improved biological activity and pharmacokinetic properties compared to their natural counterparts. OMEICOS’ technology is based on ground-breaking scientific results in the field of omega-3 fatty acid metabolism and physiology obtained by the companies’ founders, Dr. Wolf-Hagen Schunck, Prof. John. R. Falck, Prof. Dominik Mueller and Dr. Robert Fischer. The companies’ research activities are supported by a grant from the German Ministry of Education and Research (BMBF). www.omeicos.com

About High-Tech Gründerfonds
High-Tech Gründerfonds (HTGF) is a seed investor that finances high-potential, tech-driven start-ups. With € 892.5 million in total investment volume across three funds (€ 272 million in HTGF I, € 304 million in HTGF II and € 316.5 million for HTGF III) and an international partner network, HTGF has already backed up 500 start-ups since 2005. Driven by their expertise, entrepreneurial spirit and passion, its team of experienced investment managers and start-up experts help guiding the development of young companies. HTGF’s focus is on high-tech start-ups across a range of sectors, including software, media, internet, hardware, automation, healthcare, chemicals and life sciences. Up to now, external investors have invested over € 1,8 billion into the HTGF portfolio via more than 1,300 follow-on financing rounds. HTGF has also successfully exited shares of more than 90 companies.
Investors in this public-private partnership include the Federal Ministry For Economic Affairs and Energy, the KfW Banking Group, Fraunhofer-Gesellschaft e.V., as well as the companies LTANA, BASF, BAYER, B.Braun, Boehringer Ingelheim, Robert Bosch, BÜFA, CEWE, Deutsche Post DHL, Dräger, Drillisch AG, EVONIK, EWE AG, Haniel, Hettich, Knauf, Körber, LANXESS, media + more venture Beteiligungs GmbH & Co. KG, PHOENIX CONTACT, Postbank, QIAGEN, RWE Generation SE, SAP, Schufa, Schwarz Gruppe, STIHL, Thüga, Vector Informatik, WACKER and Wilh. Werhahn KG.

www.htgf.de